2007: Making giant vesicles just like blowing soap bubbles!

“Formation of giant vesiclelike compartments from a planar lipid membrane by a pulsed jet”
Published in K. Funakoshi, H. Suzuki, S. Takeuchi, J. Am. Chem. Soc., 129, pp. 12608-12609, 2007.

We report a straightforward method for the preparation of lipid vesicles inspired by forming soap bubbles from a soap film. Vesicles are mechanically blown out of a preformed biofunctional planar lipid membrane by applying a short pulsed liquid jet flow ejected from a fine jet nozzle brought near the membrane. This method allows us to directly encapsulate any molecules or substances of interest into the uniformly sized vesicles in a short time.